Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Shox2  SHOX homeobox 2   (Synonyms: 6330543G17Rik, Og12x, Prx3)
Results	Reference
1	J:135454 Blaschke RJ, Hahurij ND, Kuijper S, Just S, Wisse LJ, Deissler K, Maxelon T, Anastassiadis K, Spitzer J, Hardt SE, Scholer H, Feitsma H, Rottbauer W, Blum M, Meijlink F, Rappold G, Gittenberger-de Groot AC, Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development. Circulation. 2007 Apr 10;115(14):1830-8
1*	J:165759 Chiu HS, Szucsik JC, Georgas KM, Jones JL, Rumballe BA, Tang D, Grimmond SM, Lewis AG, Aronow BJ, Lessard JL, Little MH, Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiation. Dev Biol. 2010 Aug 15;344(2):1071-87
1	J:107668 Cobb J, Dierich A, Huss-Garcia Y, Duboule D, A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4511-5
1	J:311931 Duboc V, Sulaiman FA, Feneck E, Kucharska A, Bell D, Holder-Espinasse M, Logan MPO, Tbx4 function during hindlimb development reveals a mechanism that explains the origins of proximal limb defects. Development. 2021 Oct 1;148(19):dev199580
1*	J:328711 Fernandez-Guerrero M, Zdral S, Castilla-Ibeas A, Lopez-Delisle L, Duboule D, Ros MA, Time-sequenced transcriptomes of developing distal mouse limb buds: A comparative tissue layer analysis. Dev Dyn. 2022 Sep;251(9):1550-1575
1*	J:209070 Glaser A, Arora R, Hoffmann S, Li L, Gretz N, Papaioannou VE, Rappold GA, Tbx4 interacts with the short stature homeobox gene Shox2 in limb development. Dev Dyn. 2014 May;243(5):629-39
1	J:334725 Markman S, Zada M, David E, Giladi A, Amit I, Zelzer E, A single-cell census of mouse limb development identifies complex spatiotemporal dynamics of skeleton formation. Dev Cell. 2023 Apr 10;58(7):565-581.e4
1	J:217206 Neufeld SJ, Wang F, Cobb J, Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb. Genetics. 2014 Nov;198(3):1117-26
1	J:261810 Osterwalder M, Barozzi I, Tissieres V, Fukuda-Yuzawa Y, Mannion BJ, Afzal SY, Lee EA, Zhu Y, Plajzer-Frick I, Pickle CS, Kato M, Garvin TH, Pham QT, Harrington AN, Akiyama JA, Afzal V, Lopez-Rios J, Dickel DE, Visel A, Pennacchio LA, Enhancer redundancy provides phenotypic robustness in mammalian development. Nature. 2018 Feb 8;554(7691):239-243
1*	J:157955 Pennimpede T, Cameron DA, MacLean GA, Petkovich M, Analysis of Cyp26b1/Rarg compound-null mice reveals two genetically separable effects of retinoic acid on limb outgrowth. Dev Biol. 2010 Mar 1;339(1):179-86
1	J:313340 Rosin JM, Kurrasch DM, Cobb J, Shox2 is required for the proper development of the facial motor nucleus and the establishment of the facial nerves. BMC Neurosci. 2015 Jul 9;16:39
1	J:170400 Vickerman L, Neufeld S, Cobb J, Shox2 function couples neural, muscular and skeletal development in the proximal forelimb. Dev Biol. 2011 Feb 15;350(2):323-36
1	J:101732 Yu L, Gu S, Alappat S, Song Y, Yan M, Zhang X, Zhang G, Jiang Y, Zhang Z, Zhang Y, Chen Y, Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate. Development. 2005 Oct;132(19):4397-406
1	J:183887 Zhang Y, Blackwell EL, McKnight MT, Knutsen GR, Vu WT, Ruest LB, Specific inactivation of Twist1 in the mandibular arch neural crest cells affects the development of the ramus and reveals interactions with hand2. Dev Dyn. 2012 May;241(5):924-40